An ABO-Incompatible kidney transplant is a procedure where a donor and recipient have different or incompatible blood types. Normally, kidney transplants require matching blood types to prevent the recipient’s immune system from attacking the transplanted organ. However, with advances in medical treatment, ABO-incompatible transplants have become possible.

Why is ABO Incompatible Transplantation Needed?

• Expands the donor pool, reducing waiting times.
• Helps patients who have a willing but ABO-incompatible living donor.
• Increases the chances of receiving a transplant instead of waiting for a deceased donor.

Challenges in ABOi Transplants

• The recipient's immune system has pre-existing anti-A or anti-B antibodies that can attack the donor kidney.
• Risk of hyperacute rejection, which can cause immediate graft failure.
• Higher risk of antibody-mediated rejection (AMR) compared to ABO-compatible transplants.

How is ABOi Kidney Transplant Made Possible?

To prevent rejection, special treatments are used to reduce or remove the recipient’s harmful antibodies before transplantation:

Plasmapheresis (Plasma Exchange)

• A procedure that removes anti-A or anti-B antibodies from the blood.
• Typically performed multiple times before and after the transplant.

Immunosuppressive Therapy

• Medications like Rituximab (anti-CD20 antibody) help reduce B-cells that produce antibodies.
• Other drugs like tacrolimus, Mycophenolate Mofetil (MMF), and steroids help suppress the immune response.

Intravenous Immunoglobulin (IVIG)

• Helps modulate the immune system and reduce antibody activity.

Splenectomy (Rarely Used Today)

• Involves the removal of the spleen to reduce antibody production.
• Mostly replaced by Rituximab therapy.

Outcomes & Success Rates

• ABO-incompatible kidney transplants now have success rates comparable to ABO-compatible transplants, especially with proper desensitization.
• The 5-year survival rate is similar to that of ABO-compatible transplants when protocols are followed correctly.
• However, early rejection episodes are more common, requiring close monitoring.

Alternatives to ABO Incompatible Transplant

• Paired Kidney Exchange (Swap Transplant): If a recipient has an incompatible donor, they can swap kidneys with another incompatible pair.
• Desensitization Therapy for Highly Sensitized Patients: Additional treatments to lower antibodies.

Why Tender Palm Hospital for ABO-Incompatible Kidney Transplant?

Finding a suitable kidney donor can be challenging, particularly for a blood group incompatibility while we fill the void with hope by offering our ABO-incompatible (ABO-incompatible) kidney transplant facility and make transplantation a success despite the blood group problem. With the latest medical equipment and a team of internationally renowned specialists, we provide the best outcomes for patients. Here are some reasons why Tender Palm Hospital is your best option for ABO-incompatible kidney transplantation:-

ABO Compatible Kidney Transplant Team

Our dexterous nephrologists, transplant surgeons, immunologists, and intensive care specialists are best suited to carry out ABO-incompatible kidney transplants. Their vast experience guarantees high success rates with no complications.

State-of-the-Art Desensitization Therapies

With vast ABO-incompatible transplants, we reduce the native antibodies of the recipient against the donor blood group, so we use high-technology desensitization therapies such as:-

• Plasmapheresis (Plasma Exchange): Removes harmful antibodies from blood.
• Immunosuppressive Therapy: Suppresses the immune system to avoid rejection.
• Intravenous Immunoglobulin (IVIG) Therapy: Controls the immune system for a successful transplant.
• All of these high-technology therapies induce compatibility and enhance long-term kidney function.

State-of-the-Art Infrastructure & Facilities

Tender Palm Hospital boasts state-of-the-art transplant operating theaters, advanced ICUs, and diagnostic laboratories to provide the highest level of care at each phase of the transplant procedure. Our facilities render transplantation safe and successful even in difficult cases.

ABO-Incompatible Transplant Services

We offer the entire spectrum of ABO-incompatible kidney transplant procedures, such as:-

• Living donor ABO-incompatible transplants
• Paired kidney exchange programs for incompatible donor-recipient pairs
• Personalized pre- and post-transplant care to maximize patient outcomes

High Success Rates & Long-Term Care

We follow world's best practice in ABO-incompatible kidney transplant with high success rates and high long-term graft survival rates. We offer long-term post-transplant care, drug treatment, and lifestyle counseling for long-term kidney function as well.

Caring & Individualized Support for Patients

We are aware that ABO-incompatible transplant patient may be intimidating. To offset this, our sensitive transplant coordinators, counselors, and dietitians offer emotional, psychological, and nutritional guidance to facilitate recovery of the patient and family smoothly.

We achieve the impossible at Tender Palm Super Specialty Hospital by turning ABO-incompatible kidney transplant into reality with entire care, precision, and understanding. If your kidney or that of your family member is posing you a difficulty of compatibility, no need to worry, we are here at every step.

Conclusion

ABO-incompatible kidney transplantation has significantly improved organ transplant opportunities, especially for those with willing but incompatible donors. Although it requires careful planning and advanced immunosuppressive treatment, it has proven to be a life-saving option for many patients.

To seek an expert consultation

Call us at +91-9076972161
Email at care@tenderpalm.com

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